Tramadol works through modulation of the GABAergic, noradrenergic and serotonergic systems. It also has mild agonism of the μ-opioid receptor. Non-opioid activity contributes by the analgesic effect of tramadol. However, this can not entirely by the μ-opioid receptor antagonist naloxone be antagonized. Tramadol is the meaning of serotonergic modulating properties that it has the ability to interact, with other serotonergic. But the risk increases when
ultram pills is taken in combination with factor serotonin reuptake inhibitors. It can cause serotonin syndrome. This is because representatives of the effect of 5-HT in addition to inhibiting tramadol metabolism potentates. These antagonistic effects make Tramadol a potential applicant for people in neuropathic pain states.